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450%. it is necessary that any change within the inducer is gradual, and if necessary, changed by using a non-inducer (e.g. sodium valproate). Concomitant usage of quetiapine and thioridazine brought on an increased clearance of Vesparax Fumarate with approx. 70%. The pharmacokinetics of lithium were not altered when co-administered with Vesparax F